Harket sang the lead vocal using a Neumann U47 microphone as well as a Neve microphone pre-amp and Neve equaliser. A LinnDrum drum machine was used on the second and third releases, with acoustic cymbals and hi-hat overdubbed. The instrumentation included a Yamaha DX7 and PPG Wave, with Furuholmen playing the main melody on a Roland Juno-60. The song was produced using the Roland Juno-60 synthesiser for the main riff, along with the Yamaha DX7 and PPG Wave synthesizers. After this, Warner Brothers' main office in the United States decided to invest in the band, and gave them the opportunity to re-record the song. The band rushed to release "Take On Me" as a single in the United Kingdom but the single only charted at 137, the lowest-charted of all A-ha songs. The sound was not what A-ha had hoped to achieve, and the album was remixed again. The band met with producer Tony Mansfield, an expert in the use of the Fairlight CMI, who mixed the demos with electronic instrumentation. After a few meetings, Slater signed them with Warner Bros. With this encouragement, the band managed to complete some songs, including "Take On Me". The band signed with Ratcliff, who introduced them to manager Terry Slater. They decided to record new demos, and chose the studio of musician and producer John Ratcliff, intending to re-record five songs. A-ha returned to Norway to earn some money when they returned to London, they left Lionheart out of frustration. After a few meetings with various A&R personnel, they signed with the publishing house Lionheart. The band moved into an apartment in London and began contacting record companies and publishing houses. They intended the song to show off Harket's vocal range, which led to his vocals "doing this spiralling thing". In January 1983, the band returned to London in search of a recording contract. The three lads began working on demos, including a new version of the song, which was renamed "Lesson One" before it evolved into "Take On Me". They were joined by their school friend, singer Morten Harket, who heard the song and said the keyboard riff had the character of a universal hit sound. Waaktaar and Furuholmen relocated to London to try their hand in the music industry there, but returned to Norway after six months of disappointment. Waaktaar considered the song too poppy for their intended dark style, but Furuholmen recalled thinking it was "quite catchy". The first take of the song was inspired in part by Doors member Ray Manzarek and his "almost mathematical but very melodic, structured way of playing". Initially the band felt the riff was too pop-oriented for their band, thus the first version of the song was more "punky" in an attempt to offset the riff. "Take On Me" originated from Pål Waaktaar's and Magne Furuholmen's previous band Bridges, who first composed a number called "The Juicy Fruit Song" when they were 15 and 16 years old. The video won six awards and was nominated for two others at the 1986 MTV Video Music Awards. In the United States in October 1985, the single topped Billboard's Hot 100, bolstered by the wide exposure on MTV of director Steve Barron's innovative music video featuring the band in a live-action pencil-sketch animation sequence. The second of those 1985 releases charted in September 1985, reaching number two on the UK Singles Chart in October. The original 1984 version "Take On Me" failed to chart in the United Kingdom, as did the second version in the first of its two 1985 releases. The recording combines synth-pop with a varied instrumentation, including acoustic guitars, keyboards, and drums. The 1985 international hit version was produced by Alan Tarney for the group's debut studio album, Hunting High and Low (1985). The original version, recorded in 1984 and released in October of that same year, was produced by Tony Mansfield and remixed by John Ratcliff. " Take On Me" is a song by the Norwegian synth-pop band a-ha. "Take On Me" (original version) on YouTube
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2) therefore, addition of an add-on therapy may be considered to be a more effective and safer treatment strategy 11, 12, 13. In addition, evidence suggests that the ICS dose–response curve is relatively flat, with 80–90% of the maximum achievable therapeutic effect in adult asthma obtained at 200–250 μg of fluticasone propionate or equivalent (Fig. Add-on treatments may therefore be required 9. In addition, most of the clinical benefit of ICS use is seen at low doses. However, if asthma remains uncontrolled despite medium-dose ICS, increasing the dose of ICS may not be appropriate due to an increased risk of local and systemic side effects and variation in individual ICS dose-responsiveness between patients. Inhaled corticosteroids (ICS) are considered an effective long-term controller treatment in the management of asthma 10. The Global Initiative for Asthma (GINA) strategy recommends a stepwise approach to asthma management in order to achieve symptom control and prevent future risks, including exacerbations, loss of lung function, and side effects of medication (Fig. Reducing asthma symptoms and future risk through correct add-on therapy and management in patients who remain uncontrolled despite treatment is a major challenge for those working in both secondary and primary care. Physicians may underestimate the prevalence and severity of symptoms and overestimate the degree to which the patient’s asthma is controlled, meaning the patient may not receive adequate medication to achieve control of their disease 2, 7. It has been suggested that patients may overestimate and thus inaccurately report their level of disease control, because they accept and tolerate a certain level of symptoms, assuming them to be an inevitable consequence of asthma 7, 8. Many patients with asthma remain symptomatic, despite treatment, for multiple different reasons 2, 3, 4, 5, 6. This information could aid decision-making in primary care, supporting the use of add-on therapy to ICS to help improve lung function, control asthma symptoms and prevent exacerbations.Īsthma is a serious global health issue that affects all age groups, with a reported 339 million sufferers worldwide, presenting a number of challenges for primary care physicians 1. In children, results were positive and comparable between therapies, but data are scarce. In adults, LAMAs and LABAs provide a greater improvement in lung function than LTRAs as add-on to ICS. We explore the challenges of asthma management in primary care and review outcomes from randomised controlled trials and meta-analyses comparing the long-acting muscarinic antagonist (LAMA) tiotropium with long-acting β 2-agonists (LABAs) or leukotriene receptor antagonists (LTRAs) as add-on to ICS in patients with asthma. However, many patients remain poorly controlled, and evidence-based algorithms to decide on the best order and rationale for add-on therapies are lacking. The Global Initiative for Asthma recommends a stepwise approach to adjust asthma treatment to the needs of individual patients inhaled corticosteroids (ICS) remain the core pharmacological treatment. They need maintenance every six months to keep them running at peak performance. Regular Maintenance is one of the Cons of Reme Halo Air Cleaner Therefore, if one of your top priorities is improving the air quality of your home, and you would like to avoid spending a lot of money on an air purifier, you should consider using something else. However, they also happen to be some of the most effective. A unit alone costs around $600 apart from the installation charges. Reme Halo air purifiers are some of the most expensive on the market. Now, let’s come to the Potential Cons of Reme Halo Air Cleaner systems. 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The small and lightweight device is a great way to promote a healthy and disease-free environment in your home. In addition, it is capable of removing dust mites, pollen, mold spores, and other contaminants from the air. Your indoor air will be free of bad odors and pollutants with this air purifier. This device is effective at removing pollutants and allergens from the air, and it can help improve the quality of the air in your home. It's a whole-house air purifier that uses electromagnetic technology to clean the air. Whole House Protection is one of the Pros of Reme Halo Air Cleaner It is designed to be used in any room that requires odor removal, including the bathroom, kitchen, and pet area. The Reme Halo Purifier uses ultraviolet light to kill bacteria, viruses, and other microorganisms, and it also has a carbon filter to block out pollutants and bad odors. It blocks the entry of pollutants and odor that can help keep your home clean and fresh. The Reme Halo air cleaner effectively removes pollutants, particles, and allergens from the air. It is a small, wall-mounted device that uses patented plasma technology to clean the air. Reme Halo air cleaner is a new and innovative way to improve your indoor air quality. The supportive evidence is the pros of the Reme Halo air purifier itself. If you can sleep at night knowing that the air in your home is clean, you can relax and go about your day knowing that you've made a great investment in protecting your family's health. Plus, it's lightweight enough to move throughout your house without much trouble. What are the Pros of Reme Halo Air Purifier? The exploration covers all the potential pros and cons of the Reme Halo air purifier, from availability to efficacy. A Reme Halo Air Purifier will filter any negative elements in the air, making it safer for everyone in your home. Toxins like dander, pet hair, dust mites, and smoke will make your family sick over time. But little did you know that indoor air has four times more toxins than outdoor air. Everyone knows that air in your home is nowhere near as good as the air found outside. Reme Halo Air Purifiers have received more attention during the Covid-19 pandemic as many homeowners switched to the small, lightweight device to keep dangerous airborne elements at bay. Forensic Computer Analyst: Conducts forensic analyses of digital and other multimedia evidence in support of criminal and administrative investigations. Data Analyst: Contributes to headquarters intelligence development, investigative analyses, and audit activities.Develops cloud-based architectures to meet requirement of new and existing applications and services.
They then elected to intentionally walk Rizzo to try to get Stanton to hit into a double play, but a wild pitch advanced the runners and made that impossible. The Reds brought in Alexis Díaz, and he did his job at first, striking out Judge swinging with LeMahieu as the automatic runner at second. In a bad stretch of games where plenty of the pitchers haven’t come through when needed, King was up to the task. But King came up big, striking out pinch-hitter Matt Reynolds and getting Farmer to hit into a double play, keeping things tied. Michael King entered in the tenth, and a Stephenson single promptly moved automatic runner Votto to third base. With runners at second and third, Holmes got Pham to fly out and Votto to ground out, keeping the score tied, and when Hunter Strickland kept the Yankees off the bases, the game went to extra innings. Drury then hit a ball to third that Donaldson probably should have converted into an out, but he couldn’t handle it and Drury got an infield single. He walked Fairfield to lead off the frame, but followed it up with a strikeout to India. And while he didn’t give up any runs this time, it was still an inning to raise your blood pressure. Twenty-four hours after his blown save, Clay Holmes trotted right back out to try to keep things tied in the top of the ninth. Donaldson followed with a walk to load the bases, then IKF ripped a double into the gap to clear the bases and give the Yankees the lead. Rizzo advanced but then strayed too far past second base, so he appeared to be caught in a rundown until the Reds didn’t get anyone to cover second base in time, so he was able to get back safely. Stanton flew out for two outs, then Gleyber Torres singled to drive in LeMahieu, making it 4-2. (Home plate umpire Nick Mahrley called a huge strike zone all night, to the ire of both teams.) Anthony Rizzo then hit a ball straight to India that was destined to be an out and maybe even a double play, but he let it get past him to the outfield, plating Gallo. DJ LeMahieu singled, but Aaron Judge then stuck out looking on what was clearly a ball inside. Joey Gallo started the inning with a walk. It was a bad third inning for the Reds, exacerbated by poor defense. The second time through the order, though, the Yankees got to Minor as you’d expect they would. IKF hit a two-out double in the bottom of the second, but Higgy couldn’t drive him in. The early frustration of the Reds taking the lead was compounded by the Yankees’ inability to get to the struggling Mike Minor for the first two innings. Albert Abreu and Wandy Peralta got the Yankees through the seventh with no further damage. Sears finished with 3.2 innings pitched, two earned runs, one walk, and five strikeouts. However, he did give up a lead in the fifth (we’ll get back to that lead in a bit), after a Votto RBI double and a Stephenson sac fly made it 6-5, Cincinnati. He stabilized things, pitching a clean third and fourth inning, with three strikeouts. Considering his lengthy injury history, it’s a nail-biting time as we wait for more details. It was later reported that he left with right shoulder stiffness. None of his pitches were working, and his fastball velocity was noticeably down.Īnd so, while throwing his warmup pitches for the third inning, Sevy decided he couldn’t keep going and removed himself from the game. He got the next three outs, but was at 43 pitches through two innings pitched. He and Kyle Higashioka seemed to have a bit of trouble getting on the same page.Įven worse, Kyle Farmer, Mike Moustakas, and Stuart Fairfield hit back-to-back-to-back solo home runs to start the second inning, making it 4-0. Severino also walked Tyler Stephenson before getting out of the inning, so he had to work a lot. After Tommy Pham grounded out and moved the runners up, Joey Votto hit a line drive right to IKF that just hit the dirt before he caught it, allowing India to score. Severino looked shaky out of the gate, walking Jonathan India to lead off the game. The Reds were the last to score last night and the first to score today. But the bullpen calmed the game down, Isiah Kiner-Falefa got a huge hit, and it was the other team that melted down this time to get the Yankees a walk-off win on the tenth after two wild pitches. Luis Severino looked flat-out bad and eventually departed after only two innings and his team down 4-0 with what’s been reported as right shoulder soreness. After three ugly losses, this one looked like it might stretch the losing streak to four games. |
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